If you frequently travel with clothing made of certain fabrics, you’ll want to confirm that the spray you choose is compatible with those clothes. If you're not sure about a particular garment, spray a small section on the inside to see if it leaves a stain before spraying the entire piece. Some sprays aren’t compatible with certain fabrics, like synthetics or silk. Tips for Buying Wrinkle-release Spray Make sure it's compatible with the fabrics you wear